TENNESSEE (1-6) at SAN FRANCISCO (3-4)

4:15 p.m. ET, CBS

OPENING LINE — 49ers by 6

RECORD VS. SPREAD — San Francisco 5-1-1; Tennessee 2-5

SERIES RECORD — 49ers lead 7-4

LAST MEETING — Titans beat 49ers 33-22, Nov. 27, 2005

LAST WEEK — Titans beat Jaguars 30-13; 49ers lost to Colts 18-14

TITANS OFFENSE — OVERALL (19), RUSH (2), PASS (26)

TITANS DEFENSE — OVERALL (31), RUSH (18), PASS (32)

49ERS OFFENSE — OVERALL (27), RUSH (22), PASS (22)

49ERS DEFENSE — OVERALL (20), RUSH (2), PASS (28T)

STREAKS, STATS AND NOTES — Teams haven’t played at Candlestick Park in more than 10 years since 49ers’ 24-22 win Oct. 3, 1999 — Titans’ first loss after 3-0 start during their Super Bowl season and first year as Titans after formerly being Oilers. ... 49ers coach Mike Singletary and Titans coach Jeff Fisher were drafted same year by Chicago, 1981, Singletary in second round and Fisher in seventh. ... Titans have won five straight regular-season matchups vs. NFC. ... Tennessee snapped 0-6 start and eight-game skid overall by beating Jacksonville last Sunday coming off its bye week. QB Vince Young started for first time in more than a year and completed 15 of 18 passes for 125 yards and a TD and INT. ... 49ers have lost three straight following 3-1 start, last two by a combined seven points. ... QB Alex Smith will make his first start at home since Oct. 28, 2007, and he hasn’t won at Candlestick Park since ’07 season opener. ... San Francisco lost two key players to injury after last Sunday’s loss: LT Joe Staley for six weeks with sprained right knee and CB Nate Clements for six to eight weeks with a broken right shoulder blade. ... TE Vernon Davis leads NFL with seven TD catches and is on pace for career highs in receptions and yards.