SAN FRANCISCO — Barry Bonds took a seat in the dugout after his first home run trot of 2007 and hardly looked winded.

His legs feel great, he’s completely healthy — and ready to chase Hammerin’ Hank.

Bonds moved a step closer to Hank Aaron’s home run record Wednesday night, hitting his 735th homer in the first inning of the San Francisco Giants’ 5-3 loss to the San Diego Padres, who got a tiebreaking two-run homer from Adrian Gonzalez in the eighth.

Bonds sent a 2-2 pitch from right-hander Chris Young into the first row of seats in left-center for a solo shot and a 1-0 Giants lead, pulling the slugger within 21 of passing Aaron’s 755. Moments later, “735” flashed across the new high-definition scoreboard in center field and Bonds pointed to his daughter, Aisha, and Sue Burns, the wife of late Giants ownership partner Harmon Burns who was honored on opening day with a moment of silence.

Bonds also became the San Francisco leader for runs scored at 1,481, passing his godfather, Willie Mays’ 1,480. Bonds waved and tipped his cap when he came out to play defense in the top of the second.

Then in the third, he made a running catch with his glove outstretched on Brian Giles’ shallow fly along the left-field line, and Bonds’ momentum carried him all the way to the entrance in front of the San Francisco dugout. The 42-year-old slugger immediately dropped into a squat to catch his breath, then headed down the tunnel to recover.

He grounded out in the third, flied out in the fifth and struck out swinging in the seventh.