NEW YORK — Pfizer Inc., struggling with fierce competition from makers of generic drugs, announced Monday it will cut 10,000 jobs and close at least five facilities to slash its annual costs by up to $2 billion by next year.

OXFORD, Ohio — A clothing company founded by Irish rocker and humanitarian Bono and his wife has partnered with college students in Ohio on a business project they expect to roll out to other campuses around the world.

LONDON — Location, location, location. Almost anywhere else, the tiny dilapidated studio wouldn’t attract much more than mice. But this is London and the 77-square-foot former storage room — slightly bigger than a prison cell and without electricity — is going for $335,000.

Every other Tuesday the Napa Valley Register’s Business Focus features “BuildingBusiness,” highlighting local building or construction projects. Readers are encouraged to suggest projects to be profiled.